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Daniel E. Gottschling, Ph.D.

Photo of Daniel Gottschling

TitleMember
DepartmentDivision of Basic Sciences
InstitutionFred Hutchinson Cancer Research Center
Address1100 Fairview Avenue N
 Mailstop A3-025
 P.O. Box 19024
City, State, ZipSeattle, WA 98109-1024
Phone(206) 667-4494
E-Mailfhcrc.org
Websitelabs.fhcrc.org/gottschling/index.html
Research FieldMolecular Genetics
Award Year1991

Research

Our laboratory uses the budding yeast Saccharomyces cerevisiae as a model system to investigate fundamental questions in biology. One of our current areas of interest is understanding the striking link between increasing age and the incidence of cancer in humans. A hallmark of cancer, genomic instability, is observed in all types of organisms including yeast. We recently discovered that as yeast cells enter the middle-to-late period of their replicative lifespan, they switch to a state of high genomic instability that persists until death. We believe this change represents a fundamental transition in many aging cells and thus are taking a number of approaches to understand the mechanism underlying this phenomenon.

Keywords


1991 Scholars


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