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Marnie E. Halpern, Ph.D.

Photo of Marnie Halpern

TitleStaff Member
 Adjunct associate professor, Johns Hopkins University
DepartmentDepartment of Embryology
InstitutionCarnegie Institution of Washington
Address3520 San Martin Drive
City, State, ZipBaltimore, MD 21218
Phone(410) 246-3018
E-Mailciwemb.edu
Websitewww.ciwemb.edu/labs/halpern/index.php
Research FieldDevelopmental Neurobiology
Award Year1995

Research

One of the questions my laboratory has been studying is how differences are established between the left and right sides of the developing brain. In fish, amphibians and reptiles, the dorsal most region of the diencephalon, the epithalamus, exhibits notable left-right asymmetry in structure and in gene expression. Such differences also affect neural connections onto the midbrain target and, presumably, influence behavior. We have been performing screens to identify the genes that control asymmetry of the brain and we have developed methods to perturb laterality. We are also working on in vivo methods to visualize neural connections in the brains of altered and normal individuals. In other work, we have been generating new transgenic lines to monitor fluorescently labeled cells in the living brain, such as myelinating glia, or to perturb specific subregions by localized cell ablation.

Keywords


1995 Scholars


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