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Francis I. Valiyaveetil, Ph.D.

Photo of Francis Valiyaveetil

TitleAssistant Professor
DepartmentDepartment of Physiology and Pharmacology
InstitutionOregon Health & Science University
Address3181 SW Sam Jackson Park Road
 Mail Code L334
City, State, ZipPortland, OR 97239
Phone(503) 418-0946
E-Mailohsu.edu
Websitewww.ohsu.edu/…/valiyaveetil.cfm
Research FieldBiological Chemistry
Award Year2007

Research

We study K+ channels, which are integral membrane proteins that catalyze the selective conduction of K+ ions across biological membranes. While a great deal of research has been focused on these channels, fundamental questions regarding the mechanism of ionic selectivity and gating remain. We have developed a unique combination of methods to address these questions. Our methods include the use of chemical synthesis to introduce precise chemical changes in the channels, x-ray crystallography to determine the structural effects and electrophysiology to determine the functional effects of these changes. Using this multidisciplinary approach we are presently investigating the mechanism of K+ selectivity and the process of slow inactivation.

Keywords


2007 Scholars


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