Thomas G. Fazzio, Ph.D.

Photo of Thomas Fazzio

TitleAssistant Professor
DepartmentProgram in Gene Function and Expression
 Program in Molecular Medicine
InstitutionUniversity of Massachusetts Medical School
Address364 Plantation Street
 LRB 519
City, State, ZipWorcester, MA 01605
Phone(508) 856-6014
Research FieldStem Cells and Epigenetics
Award Year2011


We are interested in the roles of chromatin remodeling proteins in regulation of embryonic stem (ES) cell identity. While a number of transcription factors that promote ES cell self-renewal (continued proliferation as stem cells) or differentiation are known, the mechanisms by which they regulate their gene targets are mysterious. Likewise, a number of chromatin regulators are important for ES cell self-renewal or differentiation, but their functions and genomic targets are poorly understood. We are taking genetic, genomic, biochemical and molecular approaches to study the roles of chromatin remodeling proteins in ES cells. These studies should lead to a greater understanding of how chromatin regulators interface with ES cell transcription factors to maintain the transcriptome, which should ultimately pave the way for the development of ES cell-based therapies for degenerative diseases.


2011 Scholars


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